This report summarizes the MITLL-AFRL MT and ASR systems and the experiments run during the 2016 IWSLT evaluation campaign. Building on lessons learned from previous years’ results, we refine our ASR systems and examine the explosion of neural machine translation systems and techniques developed in the past year. We experiment with a variety of phrase-based, hierarchical and neural-network approaches in machine translation and utilize system combination to create a composite system with the best characteristics of all attempted MT approaches.