Electronic Medical Records (EMRs), while integral to modern healthcare, present challenges for clinical reasoning and diagnosis due to their complexity and information redundancy. To address this, we proposed medIKAL (Integrating Knowledge Graphs as Assistants of LLMs), a framework that combines Large Language Models (LLMs) with knowledge graphs (KGs) to enhance diagnostic capabilities. medIKAL assigns weighted importance to entities in medical records based on their type, enabling precise localization of candidate diseases within KGs. It innovatively employs a residual network-like approach, allowing initial diagnosis by the LLM to be merged into KG search results. Through a path-based reranking algorithm and a fill-in-the-blank style prompt template, it further refined the diagnostic process. We validated medIKAL’s effectiveness through extensive experiments on a newly introduced open-sourced Chinese EMR dataset, demonstrating its potential to improve clinical diagnosis in real-world settings.

Unified information extraction (UIE) aims to extract diverse structured information from unstructured text. While large language models (LLMs) have shown promise for UIE, they require significant computational resources and often struggle to generalize to unseen tasks. We propose RUIE (Retrieval-based Unified Information Extraction), a framework that leverages in-context learning for efficient task generalization. RUIE introduces a novel demonstration selection mechanism combining LLM preferences with a keyword-enhanced reward model, and employs a bi-encoder retriever trained through contrastive learning and knowledge distillation. As the first trainable retrieval framework for UIE, RUIE serves as a universal plugin for various LLMs. Experimental results on eight held-out datasets demonstrate RUIE’s effectiveness, with average F1-score improvements of 19.22 and 3.22 compared to instruction-tuning methods and other retrievers, respectively.

Unsupervised rationale extraction aims to extract text snippets to support model predictions without explicit rationale annotation.Researchers have made many efforts to solve this task. Previous works often encode each aspect independently, which may limit their ability to capture meaningful internal correlations between aspects. While there has been significant work on mitigating spurious correlations, our approach focuses on leveraging the beneficial internal correlations to improve multi-aspect rationale extraction. In this paper, we propose a Multi-Aspect Rationale Extractor (MARE) to explain and predict multiple aspects simultaneously. Concretely, we propose a Multi-Aspect Multi-Head Attention (MAMHA) mechanism based on hard deletion to encode multiple text chunks simultaneously. Furthermore, multiple special tokens are prepended in front of the text with each corresponding to one certain aspect. Finally, multi-task training is deployed to reduce the training overhead. Experimental results on two unsupervised rationale extraction benchmarks show that MARE achieves state-of-the-art performance. Ablation studies further demonstrate the effectiveness of our method. Our codes have been available at https://github.com/CSU-NLP-Group/MARE.

Medical Visual Question Answering (Med-VQA) seeks to accurately respond to queries regarding medical images, a task particularly challenging for open-ended questions. This study unveils the Multi-modal Concept Alignment Pre-training (MMCAP) approach for generative Med-VQA, leveraging a knowledge graph sourced from medical image-caption datasets and the Unified Medical Language System. MMCAP advances the fusion of visual and textual medical knowledge via a graph attention network and a transformer decoder. Additionally, it incorporates a Type Conditional Prompt in the fine-tuning phase, markedly boosting the accuracy and relevance of answers to open-ended questions. Our tests on benchmark datasets illustrate MMCAP’s superiority over existing methods, demonstrating its high efficiency in data-limited settings and effective knowledge-image alignment capability.

Alzheimer’s Disease (AD) is a neurodegenerative disorder that significantly impacts a patient’s ability to communicate and organize language. Traditional methods for detecting AD, such as physical screening or neurological testing, can be challenging and time-consuming. Recent research has explored the use of deep learning techniques to distinguish AD patients from non-AD patients by analysing the spontaneous speech. These models, however, are limited by the availability of data. To address this, we propose a novel contrastive data augmentation method, which simulates the cognitive impairment of a patient by randomly deleting a proportion of text from the transcript to create negative samples. The corrupted samples are expected to be in worse conditions than the original by a margin. Experimental results on the benchmark ADReSS Challenge dataset demonstrate that our model achieves the best performance among language-based models.